![]() This allows for milder reaction conditions and lower temperatures, which is particularly beneficial for sensitive isocyanides such as CNPh, CNMes or CNPh pNO2 of the present study. Results and discussion The attachment of a fluorine atom to the phenylimido ligand of increases the room temperature-solubility by a factor of 5 in both dichloromethane and acetonitrile. 1 Isocyanides used throughout this paper. In the present report, we present a series of (fluorinated) phenylimidorhenium( V) complexes with a variety of different alkyl and aryl isocyanides ( Fig. A modulation of the solubility of the phenylimido starting material without significant interference with the chemical behaviour of other ligands has recently been demonstrated with the use of p-fluoro-substituted phenylimido ligands in complexes, M = Tc or Re ( 1). esterification, formation of Schiff bases, etc.), which frequently causes undesired side-reactions and/or lower yields. 46–50 Such residues, however, sometimes undergo undesired reactions with co-ligands and/or solvents ( e.g. 37,40,44,45 Alternatively, substitutions on the arylimido ligand with the carboxylic, hydroxylic or amine group provide an enhanced solubility. The corresponding bromido complex is slightly more soluble and is, thus, occasionally used as a better suitable starting material. Thus, predominately reactions with strong chelators or with robust ligands, 22–45 which resist harsh reaction conditions, give pure products in good yields. Unfortunately, the rhenium compound is significantly less soluble than its technetium analog. 21 A similar use of the phenylimido compound as the starting material may give access to a wide variety of phenylimido complexes. The phenylimido complex is isoelectronic to the oxidorhenium( V) compound, which is frequently used as a common precursor for ligand exchange procedures. 19,20 A number of interesting reactivity features have been observed during this study, which makes it interesting to have a look at the related chemistry of rhenium. "That's what I can do with founders, coach them.Reactions of ( 3+ unit could be isolated. She never rode professionally herself, but she coaches some of the best in the world," Boyce says. "My mom is a horseback riding instructor. "This is what I was put here to do, meeting smart people and finding ways to help them," he tells us. And Grove, hardware for growing veggies in your home designed by MIT students that raised over $300,000 on Kickstarter in a couple of days.īoyce says he can't think of a more rewarding career than helping young entrepreneurs with their dreams. Then there's WorkFlow, the super popular iOS app. Some of the most successful ones include Beepi, an online marketplace for used cars. So far, Rough Draft has "backed over 50 teams, who have gone on to over $130 million of follow-on capital," Boyce says. Rough Draft originally focused just on colleges in Boston, but Boyce has recently expanded to New York and now spends his time flying between the two cities, hearing pitches. Often students use it to help them get their idea far enough along to get into an accelerator like Y Combinator, Boyce says. "It's not a crazy priced round and it's not a commitment to drop out of school," he says, referring to the pressure student founders often feel to work full time on the company once a VC funds them. ![]() What it isn't? A financing round that will get a young founder all stressed out. Those terms get worked out at a later round of funding. This is most lightweight way to do it," Boyce says, referring to a type of investment that doesn't stipulate ownership of a percentage of the company at a particular valuation. "We do uncapped convertible notes, up to $25,000. The idea is to help college kids "go from idea to products to seed and series A that are real ventures." "Not everyone has a rich uncle," Boyce jokes.įor instance, students might use it to buy a new computer, to hire a contract designer, to cover business travel expenses. They dish out small sums, up to $25,000, to help cover costs a poor student or their families can't. It often indicates a user profile.Ī meeting of the original Rough Draft Ventures crew. Account icon An icon in the shape of a person's head and shoulders. ![]()
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